In addition to the anti-virus solutions my colleague Lee Hudspeth has been outlining, safe computing these days also requires the addition of two other measures: personal firewalls and privacy shields.
My recommendation for the former is Zone Labs' Zone Alarm Pro while my recommendation for the latter is interMute's AdSubtract Pro.
The best deal is to buy the two as a bundle from AdSubtract at $39.95. Zone Labs charges 10 bucks more for the bundle; go figure. Alternatively, if you are using Symantec's Norton product lineup, you can go with Norton Internet Security 2002.
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